After several wretched months at sea, Eleanor Oliphant arrives in Calcutta with her brother Henry and sister Harriet. It is 1836, and her beloved Henry has just been appointed England's new Governor-General for India. Eleanor is to be his official hostess.

Despite the imported English gowns and formal soirees, India makes a mockery of Eleanor's sensibilities. Burning heat, starving people, insects as big as eggs--it is all an unreal dream, rife with tumultuous life. Harriet gives herself over to the adventure. Henry busies himself with official duties. Eleanor, though groping for bearings, slowly finds her isolation punctuated by moments of elation: her first monsoon, graceful women in vibrant sarees, Benares rising out of the mist. She discovers she likes curries and her native servants; and often dislikes her compatriots. Over the course of six years and a trek from Calcutta to Kabul and back, India manages to unsettle all of her "old, old ideas."