It is 1985, and Yale Tishman is the development director for an art gallery in Chicago. As his career begins to flourish, the carnage of the AIDS epidemic grows around him. One by one, his friends are dying, and after his friend Nico's funeral, the virus circles closer and closer to Yale himself. Soon the only person he has left is Fiona, Nico's little sister. Thirty years later, Fiona is in Paris tracking down her estranged daughter who disappeared into a cult. While staying with an old friend, a famous photographer who documented the Chicago crisis, she finds herself finally grappling with the devastating ways AIDS affected her life and her relationship with her daughter. In these intertwining stories, Yale and Fiona struggle to find goodness in the midst of disaster.