Florence, April 1478: The handsome Giuliano de' Medici is brutally assassinated in Florence's magnificent Duomo. The shock of the murder ripples throughout the great city, from the most renowned artists like Leonardo da Vinci and Michelangelo, to a wealthy wool merchant and his extraordinarily beautiful daughter, Madonna Lisa.

Vivacious Sancha of Aragon arrives in Rome newly wed to a member of the notorious Borgia dynasty. Surrounded by the city's opulence and political corruption, she befriends her glamorous and deceitful sister-in-law, Lucrezia, whose jealousy is as legendary as her beauty. The Borgia Bride is a richly compelling tale of conspiracy, sexual intrigue, loyalty, and drama.