1. Greg Iles quotes from Robert Penn Warren's ALL THE KING'S MEN at the start of MISSISSIPPI BLOOD. This classic novel of the American South revolves around the career of Willie Stark, a back-country lawyer whose idealism is distorted over time by his lust for power. Compare the two works, particularly Warren's depiction of the driven Willie Stark with Iles' lead character, Penn Cage.

2. What parallels can you draw between the hate group, the Double Eagles, and other modern terrorist groups? What is the Double Eagles’ ultimate purpose, and how and why does the Cage family come in conflict with them in the novel?

3. There have been many legendary courtroom scenes in Southern literature, Harper Lee's TO KILL A MOCKINGBIRD and the legal thrillers of John Grisham being two of the most memorable. How do the courtroom scenes in MISSISSIPPI BLOOD compare?

4. Penn confesses that the heroic character at the center of TO KILL A MOCKINGBIRD, Atticus Finch, was the inspiration for his desire to become a lawyer. He also says that his father, Tom, was as close as you could come to Finch in the real world. What similarities do you see between Atticus Finch, and Penn and Tom Cage?

5. Penn and his family initially question the tactics of Tom's defense attorney, Quentin Avery. To say that his legal style is unique would be a gross understatement. Discuss Avery's method of courtroom defense and whether or not you agree with it.

6. How might the story have been different if Tom allowed Penn to take a bigger role in his defense at the trial? Would the results for Tom have been any different? 

7. MISSISSIPPI BLOOD and the entire Natchez Burning trilogy have been called “an American epic.” What makes a novel or group of novels “epic,” and what other books would you include in this group?

8. Any family saga is bound to be filled with guilt. Discuss how guilt plays a part in the lives of Penn and Tom Cage, and how this shapes their behavior in the novel.

9. A dark secret from Judge Elder's past is revealed during the trial. What effect does this have on the court case?

10. Of the many characters who testify during the trial, who do you believe had the most impact on the case and why? Who do you believe was the most honest and why?

11. As the final book in a trilogy, MISSISSIPPI BLOOD brings resolution to both storylines and characters. Like any good trilogy, the characters all have their turn to shine and are changed, for better or worse, in some way. Discuss the lead characters in the Natchez Burning trilogy, the journeys they take, and how each evolves through the course of the story.